LncRNA NEAT1 is involved in temozolomide resistance by regulating MGMT in glioblastoma multiforme
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of temozolomide resistance in glioblastoma multiforme.
Glioblastoma multiforme (GBM; WHO astrocytoma grade IV) is considered incurable owing to its inherently profound resistance towards current standards of therapy. Considerable effort is being devoted to identifying the molecular basis of temozolomide resistance in GBMs and exploring novel therapeutic regimens that may improve overall survival. Several independent DNA repair mechanisms that norma...
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MicroRNAs (miRNA) are believed to play an important role in glioblastoma multiforme (GBM)chemotherapy. Our study aims to investigate potential miRNA biomarkers in GBM. Sixty GBM patients, which were given temozolomide (TMZ) chemotherapy and recurrent radiotherapy, were recruited. miRNA array was performed in cancerous and in paired normal tissues. Microarray results were further validated by a ...
متن کاملDifferential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines.
PURPOSE To investigate the radiosensitizing potential of temozolomide (TMZ) for human glioblastoma multiforme (GBM) cell lines using single-dose and fractionated gamma-irradiation. METHODS AND MATERIALS Three genetically characterized human GBM cell lines (AMC-3046, VU-109, and VU-122) were exposed to various single (0-6 Gy) and daily fractionated doses (2 Gy per fraction) of gamma-irradiatio...
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Glioblastomamultiforme (GBM) is one of themost aggressive human tumorswith apoor prognosis. Current standard treatment includes chemotherapy with the DNA-alkylating agent temozolomide concomitant with surgical resection and/or irradiation.However, anumber of cases are resistant to temozolomide-inducedDNA damage due to elevated expression of the DNA repair enzyme O-methylguanine-DNA methyltransf...
متن کاملSTAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression.
Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with a poor prognosis. Current standard treatment includes chemotherapy with the DNA-alkylating agent temozolomide concomitant with surgical resection and/or irradiation. However, a number of cases are resistant to temozolomide-induced DNA damage due to elevated expression of the DNA repair enzyme O(6)-methylguanine-DNA me...
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ژورنال
عنوان ژورنال: Clinical surgery research communications
سال: 2018
ISSN: 2573-0088,2573-0096
DOI: 10.31491/csrc.2018.3.011